China Suppliers > Tianjin Yuansu Chemical Reagent Co., LTD > N-Hydroxyethyl Benzamide
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N-Hydroxyethyl Benzamide 18838-10-3
Category : Dyestuffs and Pigments
CAS NO : 18838-10-3 EC NO : MF : C9H11NO2 MW : Specification : 99% min Packing : 25kg 50kg drum or bag Product description : What is the chemical of N-Hydroxyethyl Benzamide? Appearance: A solid ranging from pale yellow to light beige； Assay:99%min by HPLC； IR Identity: conform to standard； HNMR： conform to standard； carbon spectrum: conform to standard； Water by K. F.:0.5% max or as per the customer’s request； Loss on drying:0.5% max. or as per the customer’s request； ====================================================================================== use: N-Hydroxyethyl Benzamide) In terms of applications, this compound is primarily used as an intermediate for synthesizing other chemicals, such as in the production processes of pharmaceuticals, pesticides, or fine chemicals. =========================================================================== Synthesis route: The typical synthesis route of N - (2-hydroxyethyl) benzamide is as follows: Reaction of benzoyl chloride with ethanolamine: In an inert solvent such as dichloromethane, benzoyl chloride reacts with ethanolamine (molar ratio of approximately 1:1~1:1.2) and a base (such as triethylamine, neutralized HCl) at 0-25 ° C for 2-4 hours, followed by water washing, concentration, recrystallization, or column chromatography purification to obtain the target product with a yield of about 60-80%. Direct amidation of benzoic acid with ethanolamine: requires high temperature (>150 ° C) and dehydrating agents (such as POCl ∝, EDC, or azeotropic water removal), but with many side reactions and low yields, it is less commonly used in industry. Methyl benzoate and ethanolamine transamidation: Reflux in methanol or ethanol (60-80 ° C, several hours) to obtain the product, with mild conditions and easy removal of methanol as a byproduct, suitable for pilot testing. Uses : N-Hydroxyethyl Benzamide) In terms of applications, this compound is primarily used as an intermediate for synthesizing other chemicals, such as in the production processes of pharmaceuticals, pesticides, or fine chemicals. Synonyms : no data Molecular Structure : 
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N-Hydroxyethyl Benzamide