China Suppliers > Tianjin Yuansu Chemical Reagent Co., LTD > N-(3-chloropropyl)dibutylamine
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N-(3-chloropropyl)dibutylamine 36421-15-5
Category : Intermediates/Pharmaceutical intermediates
CAS NO : 36421-15-5 EC NO : 253-027-7 MF : C11H24ClN MW : 205.768 Specification : 99% min Packing : 25kg，50kg 200kg Product description : What is the chemical of N-(3-chloropropyl)dibutylamine ? Appearance: Colorless to pale yellow transparent oily liquid ; Assay：99%min by GC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; boiling point: 253.2 °C（760 mmHg）; ============================================================================= Main purpose: Pharmaceutical intermediate: used for synthesizing the antiarrhythmic drug Dronedarone, often referred to as "Dronedarone intermediate 2" or "Dronedarone intermediate chloropropane" Organic synthesis: used as alkylating reagents or catalysts for complex molecular construction Materials Chemistry: Can be used to prepare functional polymers or ionic liquids Daily essence: it is mentioned to be used in essence formula, but it is not the mainstream use ========================================================================== synthetic route Starting from 3- (dibutylamino) propan-1-ol, the following is synthesized through chlorination reaction: Dissolve 3- (dibutylamino) propan-1-ol (0.418 g, 2.230 mmol) in chloroform (5 mL) Slowly add thionyl chloride (0.328 mL, 4.460 mmol) through a syringe while stirring Reflux reaction for 7 hours After the reaction is complete, dilute with water and dichloromethane, and add potassium carbonate (1.2 g) for neutralization Separate the liquid and wash the organic layer sequentially with saturated sodium bicarbonate aqueous solution and water Dry with anhydrous magnesium sulfate, filter and evaporate the solvent under reduced pressure to obtain the target product Yield: Approximately 94%, as a yellow oily substance Uses : in Pharmaceutical intermediate ,Organic synthesis, Materials Chemistry and Daily essence Synonyms : 1-Dibutylamino-3-chloropropane;N-Dibutylamino-3-chloropropane;N-butyl-N-(3-chloropropyl)butan-1-amine; N-(3-Chloropropyl)dibutylamine;Dronedarone Intermediate 2; Molecular Structure : 
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N-(3-chloropropyl)dibutylamine