China Suppliers > Tianjin Yuansu Chemical Reagent Co., LTD > 4-Bromophenylacetonitrile
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4-Bromophenylacetonitrile 16532-79-9
Category : Intermediates/Pharmaceutical intermediates
CAS NO : 16532-79-9 EC NO : 240-602-2 MF : C8H6BrN MW : 196.05 Specification : 99% min Packing : 25kg 50kg drum or bag Product description : What is the chemical of 4-Bromophenylacetonitrile ? Appearance: Light yellow to light brown crystal powder ; Assay: 99% min by HPLC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; Melting point: 47–49 °C; BP: 116-118 ° C (under 3 mmHg pressure) =============================================================================== synthetic route Mainly prepared through nucleophilic substitution reaction: 1. Raw materials: 4-bromobenzyl bromide (p-bromobenzyl bromide)+sodium cyanide (NaCN) 2. Solvent: DMF water (9:1) 3. Conditions: 40 ° C, stirring for 12 hours 4. Post treatment: water quenching → ethyl acetate extraction → saturated NaCl washing → anhydrous Na ₂ SO ₄ drying → solvent evaporation under reduced pressure 5. Yield: Approximately 89% (literature value) 1 6. Alternative methods: There are also reports of using cuprous cyanide or other cyanide sources, but the NaCN method is the most common =============================================================================== main purpose Organic synthesis intermediates are widely used in the synthesis of pharmaceuticals, pesticides, dyes, fragrances, and surfactants Containing a cyanide group (- CN), it can be further converted into functional groups such as amines, carboxylic acids, amides, etc Model compounds used for studying drug absorption through the cheek Restricted for research and development purposes, not for direct human or food applications Uses : Organic synthesis intermediates are widely used in the synthesis of pharmaceuticals, pesticides, dyes, fragrances, and surfactants Synonyms : 4-bromobenzyl cyanide;Benzeneacetonitrile, 4-bromo-;P-bromobenzyl cyanide;2-(4-Bromophenyl)acetonitrile;p-Bromophenylacetonitrile; Molecular Structure : 
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4-Bromophenylacetonitrile