China Suppliers > Tianjin Yuansu Chemical Reagent Co., LTD > 4-Amino-6-chlorobenzene-1,3-disulfonamide
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- Details for 4-Amino-6-chlorobenzene-1,3-disulfonamide
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4-Amino-6-chlorobenzene-1,3-disulfonamide 121-30-2
Category : Dyestuffs and Pigments
CAS NO : 121-30-2 EC NO : 204-463-1 MF : C6H8ClN3O4S2 MW : 285.7284 Specification : 99% min Packing : 25kg 50kg drum or bag Product description : What is the chemical of 4-Amino-6-chlorobenzene-1,3-disulfonamide ? Appearance: White powder or slightly yellow crystals； Assay:99%min by HPLC； IR Identity: conform to standard； HNMR： conform to standard； carbon spectrum: conform to standard； Water by K. F.:0.5% max or as per the customer’s request； Loss on drying:0.5% max. or as per the customer’s request； =========================================================================== use: 4-Amino-6-chloro-1,3-benzenedisulfonamide, as a pharmaceutical intermediate, is widely used in the synthesis of diuretic drugs. The chlorosulfonamide group in its molecular structure is a key intermediate and active pharmaceutical ingredient for synthesizing drugs, and it is extensively applied in the industrial production of antihypertensive and edema treatment medications. ============================================================================= Synthesis route: The typical synthesis route of 4-amino-6-chloro-1,3-phenyldisulfonamide and sulfonamide is as follows: starting from m-chloroaniline, chlorosulfonation reaction is carried out to generate chlorosulfonation intermediate, which is then aminated with ammonia gas to obtain sulfonamide. Chlorosulfonation: m-chloroaniline reacts with excess chlorosulfonic acid (ClSO3H) at low temperatures (such as 0-5 ° C), and if necessary, a catalyst (such as CuCl ₂) is added or the ratio of chlorine gas/chlorosulfonic acid is controlled to generate polysulfonation intermediates such as 2-amino-4-chloro-5- (chlorosulfonyl) benzenesulfonyl chloride; Amination: Excess ammonia gas (NH3) is introduced into the chlorosulfonated product under pressure or in a solvent system (such as a water/alcohol mixed solvent), and the reaction is carried out at 40-60 ° C to selectively convert the sulfonyl chloride group to the sulfonamide group (- SO ₂ NH ₂), resulting in the crude product; Purification: Obtain high-purity target product (melting point 257-261 ° C) by dissolution (such as alkali dissolution and acid precipitation, adjusting pH 10-11 and acidifying to pH 2-4), decolorization with activated carbon, and crystallization (commonly water or ethanol water recrystallization). This route is a commonly used route for industrial preparation of impurities in hydro-chloro-thiazide (EP impurity B), avoiding the use of highly toxic phosgene or highly corrosive chlorosulfonyl chloride for direct sulfonylation, and emphasizing selectivity and safety control. There are also variants in the literature that use phosphorus trichloride assisted chlorosulfonation, but the core is still the two-step process of "chlorosulfonation → ammonolysis". Uses : 4-Amino-6-chloro-1,3-benzenedisulfonamide is mainly used as a pharmaceutical intermediate, and also serves as a key intermediate and active pharmaceutical ingredient in drug synthesis; it is widely applied in the industrial production of drugs for the tre Synonyms : 3-Chloro-4,6-disulfamoylaniline;4-Amino-6-chloro-m-benzenedisulfonamide;4-Amino-6-chlorobenzene-1,3-disulfonamide;5-Chloro-2,4-disulfamoylaniline;Chloraminophenamide;Idorese;Salmid;4-AMINO-6-CHLORO-1,3-BENZENEDISULPHONAMIDE (DSA); 4-amino-6-chloro-1,3-benzenedisulphonamide;Chloraophenamide;4-ao-6-chloro-1,3-benzenedisulphonamide;4-amino-6-chlorobenzen-1,3-disulphonamide;4-amino-6-chloro-1,3-benzene disulfonamide; Molecular Structure : 
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4-Amino-6-chlorobenzene-1,3-disulfonamide