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4-Iodobenzoic aldehyde 15164-44-0
Category : Dyestuffs and Pigments
CAS NO : 15164-44-0 EC NO : MF : C7H5IO MW : 232.0185 Specification : 99% min Packing : 25kg 50kg drum or bag Product description : What is the chemical of 4-Iodobenzoic aldehyde ? Appearance:yellow crystal powder Assay: 99% min by HPLC IR Identity: conform to standard HNMR： conform to standard carbon spectrum: conform to standard Water by K. F.:0.5% max or as per the customer’s request Loss on drying:0.5% max. or as per the customer’s request ============================================================================= Main purpose Organic synthesis intermediates: widely used for constructing complex molecular frameworks, such as drugs, natural products, and functional materials. Drug development: As an iodine containing aromatic aldehyde compound, it has potential applications in anti-tumor, antibacterial and other drug molecules. Fluorescent materials and optoelectronic materials: used for synthesizing iodine containing aromatic systems, such as iodine containing porphyrin derivatives, benzylimine monolayers, etc. Life science research: used as a biochemical reagent for labeling, coupling, or constructing probe molecules. ============================================================================= Typical synthetic route According to public information, 4-iodobenzoic aldehyde can be synthesized through the following methods: Oxidation method 4-iodobenzoic aldehyde is prepared from 4-iodotoluene by selective oxidation (such as using SeO ?, KMnO ?, or catalytic oxidation system) Formylation reaction (such as Vilsmeier Haack reaction) Introducing aldehyde groups using phenyliodate or iodobenzene as substrates under the action of Vilsmeier reagent (POCl ∝/DMF) Metal catalyzed iodo formylation cascade reaction Recent literature reports have used Pd or Cu catalytic systems to achieve direct iodoformylation in the presence of iodine sources (such as KI, I ?) and formylation reagents (such as DMF, CO) Reduction oxidation two-step method from 4-iodobenzoic acid derivatives First, reduce ethyl 4-iodobenzoate to 4-iodobenzenol (using DIBAL-H), and then oxidize it (such as TEMPO/NaOCl or MnO ?) to obtain the target product Iodization formylation one pot method Direct formylation of iodobenzene was achieved with a yield of approximately 5% using the PhI (OAc) ?/NaHCO3/CHCl3 system in the presence of amine catalysts Uses : used for pharmaceutical intermediates: for drug synthesis and natural product development. Used for industrial raw materials: applied in fields such as chemical engineering, pesticides, coatings, etc. Used for organic synth Synonyms : Benzaldehyde, 4-iodo-;NSC 84301;Benzaldehyde of iodine;P-IODOBENZALDEHYDE; Molecular Structure : 
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4-Iodobenzoic aldehyde