China Suppliers > Tianjin Yuansu Chemical Reagent Co., LTD > 4-(2-Chloroethyl)morpholine hydrochloride
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4-(2-Chloroethyl)morpholine hydrochloride 3647-69-6
Category : Intermediates/Pharmaceutical intermediates
CAS NO : 3647-69-6 EC NO : 222-881-2 MF : C6H13ClNO MW : 150.626 Specification : 99% min Packing : 25kg 50kg drum or bag Product description : What is the chemical of 4-(2-Chloroethyl)morpholine hydrochloride ? Appearance: White to beige hygroscopic crystalline powder ; Assay: 99% min by HPLC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; Melting point: 180-185 °C (dec.)(lit.); ================================================================== Mainly used in the field of pharmaceutical synthesis as an intermediate for manufacturing drugs. For example, it can be used as an intermediate for the synthesis of drugs such as nimorazole =================================================================== There are several methods for synthesizing routes, including: Method 1: Addition of morpholine and epoxyethane followed by chlorination This is the most commonly used industrial preparation method. Firstly, morpholine undergoes an addition reaction with epoxyethane to produce 2-morpholinoethanol (also known as N - (2-hydroxyethyl) morpholine). Subsequently, 2-morpholinoethanol undergoes a chlorination reaction with thionyl chloride (SOCl ₂) to replace the hydroxyl group with a chlorine atom, ultimately yielding N - (2-chloroethyl) morpholine hydrochloride. This method has relatively mild reaction conditions and high yield. Method 2: Direct reaction of 2-chloroethyl chloride with morpholine Perform nucleophilic substitution reaction between 2-chloroethyl chloride (ClCH ₂ CH ₂ Cl) and morpholine in appropriate solvents and conditions. The nitrogen atom of morpholine attacks the carbon atom in 2-chloroethyl chloride, replacing the chloride ion and directly generating N - (2-chloroethyl) morpholine hydrochloride. This route has simple steps, but the proportion of reactants needs to be controlled to avoid side reactions. Method 3: Hydrochlorination of N - (2-chloroethyl) morpholine First, synthesize N - (2-chloroethyl) morpholine (free base), and then hydrochloride it with hydrochloric acid (HCl) to obtain the target product N - (2-chloroethyl) morpholine hydrochloride. This method is suitable for synthetic pathways with specific requirements for free bases. Uses : in the field of pharmaceutical synthesis as an intermediate Synonyms : N-(2-Chloroethyl) morpholine HCl;2-(N-Morpholino)ethyl chloride hydrochloride;4-(2-chloroethyl)mopholine hydrochloride;N-(2-Chloroethyl)Morpholine Hcl;4-(2-chloroethyl)morpholine hydrochloride;4-(2-chloroethyl)morpholine hydrochloride (1:1);4-(2-chloroethyl)morpholin-4-ium; Molecular Structure : 
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4-(2-Chloroethyl)morpholine hydrochloride