China Suppliers > Tianjin Yuansu Chemical Reagent Co., LTD > 3-Amino-1,2-propanediol
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3-Amino-1,2-propanediol 616-30-8
Category : Intermediates/Pharmaceutical intermediates
CAS NO : 616-30-8 EC NO : 210-475-8 MF : C3H9NO2 MW : 91.1165 Specification : 99% min Packing : 25kg，50kg 200kg Product description : What is the chemical of 3-Amino-1,2-propanediol ? Appearance: Colorless to light yellow liquid or solid ; Assay：99%min by GC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; Melting point: 55-57°C; boiling point: 264-265 °C739 mm Hg(lit.); ============================================================================= Usage: This compound is mainly used as an organic intermediate and has important applications in the chemical and pharmaceutical fields. Its main uses include: Production of non-ionic X-CT contrast agents, especially for the synthesis of medical contrast agents such as iodixanol. Synthetic specialty materials: used as building blocks for the preparation of specific functional materials. Pesticide intermediates: Participate in the synthesis process of certain pesticides. Other uses: It can also be used as an emulsifier or in scientific research and chemical reagent fields ============================================================================= There are several methods for synthesizing routes, including: Carbon dioxide ammonia water method: 3-chloro-1,2-propylene glycol is used as the raw material to react with ammonia containing carbon dioxide to produce the intermediate aminoformic acid, which is then acidified and decomposed to obtain the hydrochloride salt. The product is then purified by desalination and distillation. one Double base catalytic method: Firstly, high-purity 3-chloro-1,2-propylene glycol is obtained by hydrolysis of epichlorohydrin, and then ammonification reaction is carried out under the catalysis of ammonia water and double bases (such as sodium carbonate and sodium hydroxide) to generate 3-amino-1,2-propanediol. one Microreactor synthesis method: Using 3-chloro-1,2-Propanediol as the raw material, sodium hydroxide solution and ammonia solution are simultaneously injected into the microreactor system. The reaction is carried out in two stages: the first stage generates glycidol, and the second stage completes the ammonolysis reaction. The total residence time is about 24 minutes, and the product yield can reach 67.4% (calculated based on the raw materials). two Epichloropropane ammonolysis method: Epichloropropane reacts directly with ammonia water to generate the target product through hydrolysis and ammonolysis steps, which is one of the commonly used routes in industry. Uses : used as an organic intermediate and has important applications in the chemical and pharmaceutical fields Synonyms : 1-Aminopropan-2,3-diol;1-amino-2,3-propanediol; 3-Amino propane-1,2-diol;1-aminopropanediol; 2,3-dihydroxypropylamine; ;3-aminopropane-1,2-diol;(2R)-2,3-dihydroxypropan-1-aminium; Molecular Structure : 
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3-Amino-1,2-propanediol