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2-Phenoxyethylamine 1758-46-9
Category : Intermediates/Pharmaceutical intermediates
CAS NO : 1758-46-9 EC NO : 217-153-6 MF : C8H12NO MW : 138.1864 Specification : 99% min Packing : 25kg，50kg 200kg Product description : What is the chemical of 2-Phenoxyethylamine ? Appearance: Colorless to pale yellow liquid ; Assay：99%min by GC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; boiling point: 101-103 °C/4 mmHg (lit.); =============================================================================== This compound is mainly used as a pharmaceutical intermediate for the synthesis of the antidepressant drug Nefazodone. Nafazone is a phenylpiperazine drug that works by inhibiting the reuptake of 5-hydroxytryptamine (5-HT) by presynaptic neurons and antagonizing the postsynaptic 5-HT2 receptor. In addition, it is also used in other organic synthesis reactions as a raw material for constructing nitrogen-containing compounds ============================================================================== There are several main synthetic routes for 2-phenoxyethylamine, but they all have certain limitations: Route 1-3: These traditional routes usually have disadvantages such as difficulty in obtaining raw materials, harsh reaction conditions, and high costs, making them unsuitable for large-scale production. Route 4: This route involves the alkylation reaction of primary amines, but the product 2-phenoxyethylamine, as the primary amine, is easily further substituted to generate secondary and tertiary amines and other by-products, resulting in a lower yield, usually around 27%. Route 5: Use epoxyethylamine as the raw material, but epoxyethylamine itself is not easy to obtain and the reaction yield is low, about 28%. Route 6: The Gabriel reaction method is used to synthesize primary amines. This method produces high purity products, but the steps are cumbersome, the overall yield is low, and the post-treatment is difficult, resulting in significant pollution. Route 7: Prepared through hydrolysis reaction, but this process requires a large amount of phosphoric acid consumption and generates a large amount of wastewater, making it difficult to achieve industrial clean production. Uses : as a pharmaceutical intermediate for the synthesis of the antidepressant drug Nefazodone Synonyms : 2-Phenoxyethanamine; Molecular Structure : 
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2-Phenoxyethylamine