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Details for China Tilmicosin

Tilmicosin 108050-54-0

Category :	Pharmaceuticals and Biochemicals
CAS NO :	108050-54-0
EC NO :
MF :	C₄₆H₈₀N₂O₁₃
MW :	869.133
Product description :	Product name: Tilmicosin. The main applicable disease: Prevention and treatment of livestock pneumonia Type: antibiotics: pharmacokinetic: This article take orally and subcutaneous injection absorb quickly, but not completely. The apparent volume of distribution, high drug concentration in lung tissue. Have good tissue penetration, can quickly and completely from the blood into the breast, breast of drug concentration is higher, long time, and half-life in milk for up to 1-2 days. Pharmacological effects: To gram-positive bacteria and some gram-negative bacteria, mycoplasma, helix, etc all have inhibition; Of actinomycetes pleura pneumonia, pasteurella than tylosin stronger antibacterial activity. Adverse reactions: forbid static note, cow a static note 5 mg/kg can be deadly, for pigs, horses and primates are also prone to death, the toxic effect of target organs is the heart, can lead to negative effects of heart. application: Mainly used for the prevention and treatment of livestock pneumonia (by pleuropneumonia actinobacillus, pasteurella, such as mycoplasma infection), avian mycoplasma disease mastitis and mammary animals. Synthesis process: Test for m star (Timicosin) is developed in the 1980 s semisynthetic large ring lactone class of livestock and poultry is special antibiotics, Molecular weight869.15. The tylosin with 3, 5 - dimethyl piperidine reaction for m star base, add phosphoric acid and water is formed for m star, it is a mixture of cis trans isomers. Test for m star is in the study of tylosin after take off sugar amination reaction of aldehyde group get the activity of a very good product, with formic acid as a catalyst for the amination reaction using Wallach reaction, can obtain a high yield for m star test. Synthetic steps: The preparation of 1, take off sugar tylosin to 19 grams tylosin phosphate dissolved in 100 ml water, slow heating to 50 ° C, and then slowly add sulfuric acid 3 ml, 1 hour 30 ° C to heat preservation, then cooled to room temperature, add 500 ml of butyl acetate, with 0.1 mol/LNaOH finally transferred to PH value of 13, to separate the organic layer, to the next step response. The preparation of 2, for m star test will tell the organic layer, add 4 ml of 3, 5 - dimethyl piperidine, heated to 70 ° C, add formate 3 ml, to separate water, 400 ml water, again with 0.1 mol/LNaOH PH adjustment to 11, with precipitation precipitation, filtration, washing, vacuum drying, the product is 15.1 g, yield of 89%. This technology USES the acid soluble alkali, alkali extraction process of soluble acid analysis, using the target compounds in water and the solubility of organic medium is different, do not need to distillation, heat, is advantageous to the promotion.
Synonyms :	20-DEOXO-20-(3,5-DIMETHYL-1-PIPERIDINYL)DESMYCOSIN;Tilmicosin, Vetranal;Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-.alpha.-L-ribo-hexopyranosyl)-20-deoxo-20-(3R,5S)-3,5-dimethyl-1-piperidinyl-;pulmotil;4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin;Antibiotic EL 870;[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]oxy}-11-{2-[(3R,5S)-3,5-dimethylpiperidin-1-yl]ethyl}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxooxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside;Tilmicosin base;
Molecular Structure :

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